O-GlcNAcylation links ChREBP and FXR to glucose-sensing

O-GlcNAcylation links ChREBP and FXR to glucose-sensing

Accumulating evidence suggests that O-GlcNAc transferase (OGT), an enzyme responsible for O-GlcNAc post-translational modification acts as a nutrient sensor that links glucose and the hexosamine biosynthetic pathway to the regulation of transcriptional factors involved in energy homeostasis. In live...

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Bibliographic Details
Main Authors: Fadila eBenhamed, Gaelle eFilhoulaud, Sandrine eCaron, Philippe eLefevbre, Bart eStaels, Catherine ePostic
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Endocrinology
Subjects:
O-GlcNAcylation
glucose-sensing
FXR
ChREBP
Liver metabolism
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00230/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00230/full

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