Muscle-type nicotinic receptor modulation by 2,6-dimethylaniline, a molecule resembling the hydrophobic moiety of lidocaine

Muscle-type nicotinic receptor modulation by 2,6-dimethylaniline, a molecule resembling the hydrophobic moiety of lidocaine

To identify the molecular determinants responsible for lidocaine blockade of muscle-type nAChRs, we have studied the effects on this receptor of 2,6-dimethylaniline (DMA), which resembles lidocaine’s hydrophobic moiety. Torpedo marmorata nAChRs were microtransplanted to Xenopus oocytes and currents...

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Bibliographic Details
Main Authors: Armando Alberola-Die, Gregorio Fernandez-Ballester, José Manuel González-Ros, Isabel Ivorra, Andrés Morales
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Lidocaine
nicotinic acetylcholine receptors
Xenopus oocytes
allosteric modulation
microtransplanted receptors
2_6-Dimethylaniline
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00127/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00127/full

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