Identifying stem cell numbers and functional heterogeneities during postembryonic organ growth

Summary: Uncovering the number of stem cells necessary for organ growth has been challenging in vertebrate systems. Here, we developed a mathematical model characterizing stem cells in the fish gill, an organ displaying non-exhaustive growth. We employ a Markov model, stochastically simulated via an...

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Bibliographic Details
Main Authors: Diana-Patricia Danciu, Julian Stolper, Lázaro Centanin, Anna Marciniak-Czochra
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422200089X