Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis

Abstract Background Grade 4 glioma is the most aggressive and currently incurable brain tumor with a median survival of one year in adult patients. Elucidating novel transcriptomic and epigenetic contributors to the molecular heterogeneity underlying its aggressiveness may lead to improved clinical...

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Bibliographic Details
Main Authors: Chang Zeng, Xiao Song, Zhou Zhang, Qinyun Cai, Jiajun Cai, Craig Horbinski, Bo Hu, Shi-Yuan Cheng, Wei Zhang
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Acta Neuropathologica Communications
Subjects:
Online Access:https://doi.org/10.1186/s40478-023-01619-5