Robust drug bioavailability and safety for rheumatoid arthritis therapy using D-amino acids-based supramolecular hydrogels

Robust drug bioavailability and safety for rheumatoid arthritis therapy using D-amino acids-based supramolecular hydrogels

Long-term use of disease-modifying anti-rheumatic drugs (DMARDs) such as methotrexate (MTX) shows clinical benefits for rheumatoid arthritis (RA) treatment. However, there are growing concerns over the adverse effects of systemic drug administration. Therefore, a strategy that can enhance drug bioav...

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Bibliographic Details
Main Authors: Shaodan Ma, Shunan Gu, Jinwei Zhang, Weizhong Qi, Zhaowei Lin, Weicheng Zhai, Jie Zhan, Qi Li, Yanbin Cai, Yao Lu
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Materials Today Bio
Subjects:
Rheumatoid arthritis
Supramolecular hydrogel
d-amino acids
Methotrexate
Drug delivery system
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006422000941

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http://www.sciencedirect.com/science/article/pii/S2590006422000941

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