Porcine Reproductive and Respiratory Syndrome Virus Engineered by Serine Substitution on the 44th Amino Acid of GP5 Resulted in a Potential Vaccine Candidate with the Ability to Produce High Levels of Neutralizing Antibody

Porcine Reproductive and Respiratory Syndrome Virus Engineered by Serine Substitution on the 44th Amino Acid of GP5 Resulted in a Potential Vaccine Candidate with the Ability to Produce High Levels of Neutralizing Antibody

N-linked glycans covering GP5 neutralizing epitopes of porcine reproductive and respiratory syndrome virus (PRRSV) have been proposed to act as a sheath blocking the production of neutralizing antibodies. Herein, we genetically engineered PRRSV with serine (S) substitution on the 44th asparagine (N)...

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Bibliographische Detailangaben
Hauptverfasser: Jong-Chul Choi, Min-Sik Kim, Hwi-Yeon Choi, Yeong-Lim Kang, In-Yeong Choi, Sung-Won Jung, Ji-Yun Jeong, Min-Chul Kim, Andrew Y. Cho, Ji-Ho Lee, Dong-Hun Lee, Sang-Won Lee, Seung-Yong Park, Chang-Seon Song, In-Soo Choi, Joong-Bok Lee
Format: Artikel
Sprache:English
Veröffentlicht: MDPI AG 2023-03-01
Schriftenreihe:Veterinary Sciences
Schlagworte:
porcine reproductive and respiratory syndrome virus
vaccine
GP5
glycosylation
neutralizing antibody
Online Zugang:https://www.mdpi.com/2306-7381/10/3/191

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https://www.mdpi.com/2306-7381/10/3/191

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