A CXCR4 receptor agonist strongly stimulates axonal regeneration after damage

Abstract Objective To test whether the signaling axis CXCL12α‐CXCR4 is activated upon crush/cut of the sciatic nerve and to test the activity of NUCC‐390, a new CXCR4 agonist, in promoting nerve recovery from damage. Methods The sciatic nerve was either crushed or cut. Expression and localization of...

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Bibliographic Details
Main Authors: Giulia Zanetti, Samuele Negro, Aram Megighian, Andrea Mattarei, Florigio Lista, Silvia Fillo, Michela Rigoni, Marco Pirazzini, Cesare Montecucco
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.50926