Computational identification of harmful mutation regions to the activity of transposable elements

Computational identification of harmful mutation regions to the activity of transposable elements

Abstract Background Transposable elements (TEs) are interspersed DNA sequences that can move or copy to new positions within a genome. TEs are believed to promote speciation and their activities play a significant role in human disease. In the human genome, the 22 AluY and 6 AluS TE subfamilies have...

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Bibliographic Details
Main Authors: Lingling Jin, Ian McQuillan, Longhai Li
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Genomics
Subjects:
Transposable elements
Harmful mutation regions
The human genome
Pearson’s coefficient of correlation
Statistical significance test
Multiple testing correction
Online Access:http://link.springer.com/article/10.1186/s12864-017-4227-z

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http://link.springer.com/article/10.1186/s12864-017-4227-z

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