Improving hematopoietic differentiation from human induced pluripotent stem cells by the modulation of Hippo signaling with a diarylheptanoid derivative

Improving hematopoietic differentiation from human induced pluripotent stem cells by the modulation of Hippo signaling with a diarylheptanoid derivative

Abstract Background The diarylheptanoid ASPP 049 has improved the quality of adult hematopoietic stem cell (HSC) expansion ex vivo through long-term reconstitution in animal models. However, its effect on hematopoietic regeneration from human induced pluripotent stem cells (hiPSCs) is unknown. Metho...

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Bibliographic Details
Main Authors: Umnuaychoke Thongsa-ad, Anongnat Wongpan, Wasinee Wongkummool, Phaewa Chaiwijit, Kwanchanok Uppakara, Gorawin Chaiyakitpattana, Passanan Singpant, Pirut Tong-ngam, Amnat Chukhan, Wachirachai Pabuprappap, Sirapope Wongniam, Apichart Suksamrarn, Suradej Hongeng, Usanarat Anurathapan, Kasem Kulkeaw, Alisa Tubsuwan, Kanit Bhukhai
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Stem Cell Research & Therapy
Subjects:
Diarylheptanoid
Human induced pluripotent stem cells
Primitive hematopoietic stem and progenitor cells
Hippo signaling pathway
Online Access:https://doi.org/10.1186/s13287-024-03686-4

Internet

https://doi.org/10.1186/s13287-024-03686-4

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