SHP2 inhibition improves celastrol-induced growth suppression of colorectal cancer

SHP2 inhibition improves celastrol-induced growth suppression of colorectal cancer

This study aimed to explore novel targets for celastrol sensitization in colorectal cancer (CRC) based on differentially regulated signals in response to high- or low-dose celastrol. Targeting signals were investigated using Western blotting or phosphorylated receptor tyrosine kinase (RTK) arrays. C...

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Bibliographic Details
Main Authors: Linxi Zhang, Xuefei Hu, Qingying Meng, Ye Li, Hao Shen, Yating Fu, Fan Zhang, Jiahui Chen, Wei Zhang, Wenjun Chang, Yamin Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
colorectal cancer
celastrol
SHP2
combined chemotherapy
growth suppression
AKT/ERK pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.929087/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.929087/full

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