Neuronal Death Caused by HMGB1-Evoked via Inflammasomes from Thrombin-Activated Microglia Cells

Neuronal Death Caused by HMGB1-Evoked via Inflammasomes from Thrombin-Activated Microglia Cells

Microglial cells are a macrophage-like cell type residing within the CNS. These cells evoke pro-inflammatory responses following thrombin-induced brain damage. Inflammasomes, which are large caspase-1-activating protein complexes, play a critical role in mediating the extracellular release of HMGB1...

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Bibliographic Details
Main Authors: Meei-Ling Sheu, Liang-Yi Pan, Cheng-Ning Yang, Jason Sheehan, Liang-Yu Pan, Weir-Chiang You, Chien-Chia Wang, Hong-Shiu Chen, Hung-Chuan Pan
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
thrombin
inflammasome
endoplasmic retinaculum stress
high-mobility group box chromosomal protein 1(HMGB-1)
Online Access:https://www.mdpi.com/1422-0067/24/16/12664

Internet

https://www.mdpi.com/1422-0067/24/16/12664

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