Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Abstract Background Preeclampsia is a pregnancy-specific hypertensive disorder characterized by impaired angiogenesis. We postulate that senescence of mesenchymal stem cells (MSC), multipotent cells with pro-angiogenic activities, is one of the mechanisms by which systemic inflammation exerts inhibi...

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Bibliographic Details
Main Authors: Sonja Suvakov, Hajrunisa Cubro, Wendy M. White, Yvonne S. Butler Tobah, Tracey L. Weissgerber, Kyra L. Jordan, Xiang Y. Zhu, John R. Woollard, Fouad T. Chebib, Natasa M. Milic, Joseph P. Grande, Ming Xu, Tamara Tchkonia, James L. Kirkland, Lilach O. Lerman, Vesna D. Garovic
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Biology of Sex Differences
Subjects:
Preeclampsia
Mesenchymal stem cells
Senescence
Angiogenesis, Senolytics, Dasatinib
Online Access:http://link.springer.com/article/10.1186/s13293-019-0263-5

Internet

http://link.springer.com/article/10.1186/s13293-019-0263-5

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