Astrocytic pyruvate dehydrogenase kinase-lactic acid axis involvement in glia-neuron crosstalk contributes to morphine-induced hyperalgesia in mice

Astrocytic pyruvate dehydrogenase kinase-lactic acid axis involvement in glia-neuron crosstalk contributes to morphine-induced hyperalgesia in mice

The activation of spinal astrocytes accounts for opioid-induced hyperalgesia (OIH), but the underlying mechanisms remain elusive. The presence of astrocyte-neuron lactate shuttle (ANLS) makes astrocytes necessary for some neural function and communication. The aim of this study was to explore the ro...

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Bibliographic Details
Main Authors: Xiaqing Ma, Qi Qi, Wenying Wang, Min Huang, Haiyan Wang, Limin Luo, Xiaotao Xu, Tifei Yuan, Haibo Shi, Wei Jiang, Tao Xu
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2024-07-01
Series:Fundamental Research
Subjects:
Pyruvate dehydrogenase kinase 4
Phosphorylated pyruvate dehydrogenase
Astrocyte-neuron lactate shuttle
Opioid-induced hyperalgesia
Lactate
Online Access:http://www.sciencedirect.com/science/article/pii/S2667325823000638

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http://www.sciencedirect.com/science/article/pii/S2667325823000638

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