Thermodynamic principle to enhance enzymatic activity using the substrate affinity

Abstract Understanding how to tune enzymatic activity is important not only for biotechnological applications, but also to elucidate the basic principles guiding the design and optimization of biological systems in nature. So far, the Michaelis-Menten equation has provided a fundamental framework of...

Full description

Bibliographic Details
Main Authors: Hideshi Ooka, Yoko Chiba, Ryuhei Nakamura
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40471-y