Endothelial-mesenchymal transition induced by metastatic 4T1 breast cancer cells in pulmonary endothelium in aged mice

Endothelial-mesenchymal transition induced by metastatic 4T1 breast cancer cells in pulmonary endothelium in aged mice

Ageing is a major risk factor for cancer metastasis but the underlying mechanisms remain unclear. Here, we characterised ageing effects on cancer-induced endothelial-mesenchymal transition (EndMT) in the pulmonary circulation of female BALB/c mice in a metastatic 4T1 breast cancer model. The effect...

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Bibliographic Details
Main Authors: Marta Smeda, Agnieszka Jasztal, Ebrahim H Maleki, Anna Bar, Magdalena Sternak, Grzegorz Kwiatkowski, Joanna Suraj-Prażmowska, Bartosz Proniewski, Anna Kieronska-Rudek, Kamila Wojnar-Lason, Klaudia Skrzypek, Marcin Majka, Karolina Chrabaszcz, Kamilla Malek, Stefan Chlopicki
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
endothelial-mesenchymal transition
ageing
age-related endothelial dysfunction
breast cancer metastasis
Raman spectroscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1050112/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.1050112/full

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