PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse Fibroblasts, with Effects on DNA Replication Dynamics, Senescence, and Oncogenic Transformation

PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse Fibroblasts, with Effects on DNA Replication Dynamics, Senescence, and Oncogenic Transformation

The regulated formation and resolution of R-loops is a natural process in physiological gene expression. Defects in R-loop metabolism can lead to DNA replication stress, which is associated with a variety of diseases and, ultimately, with cancer. The proteins PARP1, DIDO3, and DHX9 are important pla...

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Bibliographic Details
Main Authors: Agnes Fütterer, Sara Rodriguez-Acebes, Juan Méndez, Julio Gutiérrez, Carlos Martínez-A
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
<i>Dido1</i> gene
DIDO3
PARP1
DHX9
replication fork
replication stress
Online Access:https://www.mdpi.com/2073-4409/13/2/159

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https://www.mdpi.com/2073-4409/13/2/159

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