Application of 32 factorial design for loratadine-loaded nanosponge in topical gel formulation: comprehensive in-vitro and ex vivo evaluations

Application of 32 factorial design for loratadine-loaded nanosponge in topical gel formulation: comprehensive in-vitro and ex vivo evaluations

Abstract Loratadine (LoR) is a highly lipophilic and practically insoluble in water, hence having a low oral bioavailability. As it is formulated as topical gel, it competitively binds with the receptors, thus reducing the side-effects. The objective of this study was to prepare LoR loaded nanospong...

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Bibliographic Details
Main Authors: Durgaramani Sivadasan, Krishnaraju Venkatesan, Jamal Moideen Muthu Mohamed, Saud Alqahtani, Yahya I. Asiri, Mennatullah M. Faisal, Adel Ehab Ibrahim, Yahya Bin Abdullah Alrashdi, Farid Menaa, Sami El Deeb
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Nanosponge
Loratadine
Ethyl cellulose
Hydrogel
Full factorial design
Sustained release
Online Access:https://doi.org/10.1038/s41598-024-55953-2

Internet

https://doi.org/10.1038/s41598-024-55953-2

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