HipA-Mediated Phosphorylation of SeqA Does not Affect Replication Initiation in Escherichia coli

The SeqA protein of Escherichia coli is required to prevent immediate re-initiation of chromosome replication from oriC. The SeqA protein is phosphorylated at the serine-36 (Ser36) residue by the HipA kinase. The role of phosphorylation was addressed by mutating the Ser36 residue to alanine, which c...

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Bibliographic Details
Main Authors: Leise Riber, Birgit M. Koch, Line Riis Kruse, Elsa Germain, Anders Løbner-Olesen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Microbiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02637/full