TTC30A and TTC30B Redundancy Protects IFT Complex B Integrity and Its Pivotal Role in Ciliogenesis

TTC30A and TTC30B Redundancy Protects IFT Complex B Integrity and Its Pivotal Role in Ciliogenesis

Intraflagellar transport (IFT) is a microtubule-based system that supports the assembly and maintenance of cilia. The dysfunction of IFT leads to ciliopathies of variable severity. Two of the IFT-B components are the paralogue proteins TTC30A and TTC30B. To investigate whether these proteins constit...

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Bibliographic Details
Main Authors: Felix Hoffmann, Sylvia Bolz, Katrin Junger, Franziska Klose, Timm Schubert, Franziska Woerz, Karsten Boldt, Marius Ueffing, Tina Beyer
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Genes
Subjects:
cilia
IFT
TTC30 paralogues
CRISPR/Cas9
affinity proteomics
polyglutamylation
Online Access:https://www.mdpi.com/2073-4425/13/7/1191

Internet

https://www.mdpi.com/2073-4425/13/7/1191

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