Pioglitazone Is a Mild Carrier-Dependent Uncoupler of Oxidative Phosphorylation and a Modulator of Mitochondrial Permeability Transition

Pioglitazone Is a Mild Carrier-Dependent Uncoupler of Oxidative Phosphorylation and a Modulator of Mitochondrial Permeability Transition

Pioglitazone (PIO) is an insulin-sensitizing antidiabetic drug, which normalizes glucose and lipid metabolism but may provoke heart and liver failure and chronic kidney diseases. Both therapeutic and adverse effects of PIO can be accomplished through mitochondrial targets. Here, we explored the capa...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Ekaterina S. Kharechkina, Anna B. Nikiforova, Konstantin N. Belosludtsev, Tatyana I. Rokitskaya, Yuri N. Antonenko, Alexey G. Kruglov
Format: Artykuł
Język:English
Wydane: MDPI AG 2021-10-01
Seria:Pharmaceuticals
Hasła przedmiotowe:
permeability transition pore
unilamellar vesicles
adenine nucleotide translocase
uncoupling protein
ATP production
Dostęp online:https://www.mdpi.com/1424-8247/14/10/1045

Internet

https://www.mdpi.com/1424-8247/14/10/1045

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