Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications

Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications

IntroductionThe malignant transformation leading to a maturation arrest in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) occurs early in B-cell development, in a pro-B or pre-B cell, when somatic recombination of variable (V), diversity (D), and joining (J) segment immunoglobulin (IG) gene...

Повний опис

Бібліографічні деталі
Автори: Franziska Darzentas, Monika Szczepanowski, Michaela Kotrová, Alina Hartmann, Thomas Beder, Nicola Gökbuget, Stefan Schwartz, Lorenz Bastian, Claudia Dorothea Baldus, Karol Pál, Nikos Darzentas, Monika Brüggemann
Формат: Стаття
Мова:English
Опубліковано: Frontiers Media S.A. 2023-04-01
Серія:Frontiers in Immunology
Предмети:
acute lymphoblastic leukemia
clonal evolution
minimal residual disease
DNJ-stem
VH replacement
IGH rearrangements
Онлайн доступ:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125017/full

Інтернет

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125017/full

Схожі ресурси