Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39

Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39

Nsp14 is an RNA methyltransferase (MTase) encoded by all coronaviruses. In fact, many viral families, including DNA viruses, encode MTases that catalyze the methylation of the RNA precap structure, resulting in fully capped viral RNA. This capping is crucial for efficient viral RNA translation, stab...

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Bibliographic Details
Main Authors: Eva Zilecka, Martin Klima, Milan Stefek, Milan Dejmek, Radim Nencka, Evzen Boura
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Structural Biology: X
Subjects:
Methyltransferase
Inhibitor
Crystal structure
Online Access:http://www.sciencedirect.com/science/article/pii/S259015242400014X

Internet

http://www.sciencedirect.com/science/article/pii/S259015242400014X

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