Chikungunya Virus Strains Show Lineage-Specific Variations in Virulence and Cross-Protective Ability in Murine and Nonhuman Primate Models

Chikungunya Virus Strains Show Lineage-Specific Variations in Virulence and Cross-Protective Ability in Murine and Nonhuman Primate Models

ABSTRACT Chikungunya virus (CHIKV) is a reemerging arbovirus capable of causing explosive outbreaks of febrile illness, polyarthritis, and polyarthralgia, inflicting severe morbidity on affected populations. CHIKV can be genetically classified into 3 major lineages: West African (WA); East, Central,...

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Bibliographic Details
Main Authors: Rose M. Langsjoen, Sherry L. Haller, Chad J. Roy, Heather Vinet-Oliphant, Nicholas A. Bergren, Jesse H. Erasmus, Jill A. Livengood, Tim D. Powell, Scott C. Weaver, Shannan L. Rossi
Format: Article
Language:English
Published: American Society for Microbiology 2018-05-01
Series:mBio
Subjects:
alphavirus
chikungunya
vaccine
Online Access:https://journals.asm.org/doi/10.1128/mBio.02449-17

Internet

https://journals.asm.org/doi/10.1128/mBio.02449-17

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