Depleted Calcium Stores and Increased Calcium Entry in Rod Photoreceptors of the <i>Cacna2d4</i> Mouse Model of Cone-Rod Dystrophy RCD4

Depleted Calcium Stores and Increased Calcium Entry in Rod Photoreceptors of the <i>Cacna2d4</i> Mouse Model of Cone-Rod Dystrophy RCD4

Unidentified pathogenetic mechanisms and genetic and clinical heterogeneity represent critical factors hindering the development of treatments for inherited retinal dystrophies. Frameshift mutations in <i>Cacna2d4</i>, which codes for an accessory subunit of voltage-gated calcium channel...

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Bibliographic Details
Main Authors: Vittorio Vellani, Giovanna Mauro, Gian Carlo Demontis
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
cone-rod dystrophy
voltage-gated calcium channels
α<sub>2</sub>δ-4 protein
caffeine-sensitive calcium stores
non-selective cationic channels
calcium imaging
Online Access:https://www.mdpi.com/1422-0067/23/21/13080

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https://www.mdpi.com/1422-0067/23/21/13080

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