Multifaceted remodeling by vitamin C boosts sensitivity of Mycobacterium tuberculosis subpopulations to combination treatment by anti-tubercular drugs

Multifaceted remodeling by vitamin C boosts sensitivity of Mycobacterium tuberculosis subpopulations to combination treatment by anti-tubercular drugs

Bacterial dormancy is a major impediment to the eradication of tuberculosis (TB), because currently used drugs primarily target actively replicating bacteria. Therefore, decoding of the critical survival pathways in dormant tubercle bacilli is a research priority to formulate new approaches for kill...

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Bibliographic Details
Main Authors: Kriti Sikri, Priyanka Duggal, Chanchal Kumar, Sakshi Dhingra Batra, Atul Vashist, Ashima Bhaskar, Kritika Tripathi, Tavpritesh Sethi, Amit Singh, Jaya Sivaswami Tyagi
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Redox Biology
Subjects:
Mycobacterium tuberculosis
Vitamin C
Dormancy
Viable but non-culturable
Heterogeneous subpopulations
TB drugs
Antibiotic tolerance
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717308911

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http://www.sciencedirect.com/science/article/pii/S2213231717308911

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