IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity

IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity

Abstract IL-31, which is a member of the IL-6 family of cytokines, is produced mainly by activated CD4+ T cells, in particular activated Th2 cells, suggesting a contribution to development of type-2 immune responses. IL-31 was reported to be increased in specimens from patients with atopic dermatiti...

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Main Authors: Ayako Takamori, Aya Nambu, Keiko Sato, Sachiko Yamaguchi, Kenshiro Matsuda, Takafumi Numata, Takeru Sugawara, Takamichi Yoshizaki, Ken Arae, Hideaki Morita, Kenji Matsumoto, Katsuko Sudo, Ko Okumura, Jiro Kitaura, Hiroshi Matsuda, Susumu Nakae
Format: Article
Language:English
Published: Nature Portfolio 2018-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-25094-4

Internet

https://doi.org/10.1038/s41598-018-25094-4

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