Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice

Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice

Studies from both humans and animal models indicated that maternal chronic poor-quality diet, especially a high fat diet (HFD), is significantly associated with reduced bone density and childhood fractures in offspring. When previously studied in a rat model, our data suggested that maternal HFD cha...

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Bibliographic Details
Main Authors: Jin-Ran Chen, Perry C. Caviness, Haijun Zhao, Beau Belcher, Umesh D. Wankhade, Kartik Shankar, Michael L Blackburn, Oxana P. Lazarenko
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Epigenetics
Subjects:
high fat diet
maternal obesity
histone modification
osteoblast
Online Access:http://dx.doi.org/10.1080/15592294.2022.2111759

Internet

http://dx.doi.org/10.1080/15592294.2022.2111759

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