A protective role of ABCA5 in response to elevated sphingomyelin levels in Parkinson’s disease

A protective role of ABCA5 in response to elevated sphingomyelin levels in Parkinson’s disease

Abstract Parkinson’s disease (PD) is a chronic neurodegenerative disorder that affects the motor system. Increasing evidence indicates that lysosomal dysfunction is pivotal in the pathogenesis of PD, typically characterized by dysregulation of sphingolipids in lysosomes. ATP-binding cassette subfami...

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Bibliographic Details
Main Authors: YuHong Fu, Russell Pickford, Jasmin Galper, Katherine Phan, Ping Wu, Hongyun Li, Young-Bum Kim, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-024-00632-2

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https://doi.org/10.1038/s41531-024-00632-2

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