Identification of novel mutations of Insulin Receptor Substrate 1 (IRS1) in tumor samples of non-small cell lung cancer (NSCLC): Implications for aberrant insulin signaling in development of cancer

Identification of novel mutations of Insulin Receptor Substrate 1 (IRS1) in tumor samples of non-small cell lung cancer (NSCLC): Implications for aberrant insulin signaling in development of cancer

Abstract Lung cancer is the leading cause of cancer-related death, and NSCLC constitutes nearly 85%–90% of all cases. The IRS proteins function as adaptors and transmit signals from multiple receptors. Upon binding of insulin to the insulin receptor (IR), IRS1 is phosphorylated at several YXXM motif...

Full description

Bibliographic Details
Main Authors: Gokhan Gorgisen, Fatma Zehra Hapil, Ozlem Yilmaz, Zafer Cetin, Suray Pehlivanoglu, Irem Hicran Ozbudak, Abdullah Erdogan, Osman Nidai Ozes
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2019-02-01
Series:Genetics and Molecular Biology
Subjects:
IRS1
NSCLC
insulin signaling
lung cancer
IRS proteins
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000100015&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000100015&lng=en&tlng=en

Similar Items