Hippocampal GAD67 Transduction Using rAAV8 Regulates Epileptogenesis in EL Mice

Hippocampal GAD67 Transduction Using rAAV8 Regulates Epileptogenesis in EL Mice

Gene therapy has been employed as a therapeutic approach for intractable focal epilepsies. Considering the potential of focal GABAergic neuromodulation in regulating epileptogenesis, the GABA-producing enzyme, γ-aminobutyric acid decarboxylase 67 (GAD67), is highly suitable for epilepsy therapy. The...

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Bibliographic Details
Main Authors: Kuniko Shimazaki, Takashi Kobari, Keiji Oguro, Hidenori Yokota, Yuko Kasahara, Yoshiya Murashima, Eiju Watanabe, Kensuke Kawai, Takashi Okada
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050119300014

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http://www.sciencedirect.com/science/article/pii/S2329050119300014

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