Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms

Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms

Abstract Therapy-related myeloid neoplasms (t-MN) arise as a complication of chemo- and/or radiotherapy. Although t-MN can occur both in adult and childhood cancer survivors, the mechanisms driving therapy-related leukemogenesis likely vary across different ages. Chemotherapy is thought to induce dr...

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Bibliographic Details
Main Authors: Eline J. M. Bertrums, Jurrian K. de Kanter, Lucca L. M. Derks, Mark Verheul, Laurianne Trabut, Markus J. van Roosmalen, Henrik Hasle, Evangelia Antoniou, Dirk Reinhardt, Michael N. Dworzak, Nora Mühlegger, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Bianca F. Goemans, Ruben van Boxtel
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-50384-z

Internet

https://doi.org/10.1038/s41467-024-50384-z

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