The Anti-Histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits Infection by Major Variants of SARS-CoV-2 in Cell Cultures and Reconstituted Human Nasal Tissue

The Anti-Histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits Infection by Major Variants of SARS-CoV-2 in Cell Cultures and Reconstituted Human Nasal Tissue

Background and purpose: The COVID-19 pandemic continues to pose challenges, especially with the emergence of new SARS-CoV-2 variants that are associated with higher infectivity and/or compromised protection afforded by the current vaccines. There is a high demand for additional preventive and therap...

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Bibliographic Details
Main Authors: Robert Konrat, Henrietta Papp, Janine Kimpel, Annika Rössler, Valéria Szijártó, Gábor Nagy, Mónika Madai, Safia Zeghbib, Anett Kuczmog, Zsófia Lanszki, Tanja Gesell, Zsuzsanna Helyes, Gábor Kemenesi, Ferenc Jakab, Eszter Nagy
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
COVID-19
computational drug repurposing
SARS-CoV-2
azelastine
anti-viral activity
variants of concern
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.861295/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.861295/full

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