A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity

A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity

Abstract Background The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is mediated through the binding of the SARS-CoV-2 Spike protein via the receptor binding domain (RBD) to human angiotensin-converting enzyme 2 (hACE2). Identifying compounds that inhibit...

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Bibliographic Details
Main Authors: Shine Varghese Jancy, Santhik Subhasingh Lupitha, Aneesh Chandrasekharan, Shankara Narayanan Varadarajan, Shijulal Nelson-Sathi, Roshny Prasad, Sara Jones, Sreekumar Easwaran, Pramod Darvin, Aswathy Sivasailam, Thankayyan Retnabai Santhoshkumar
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Biological Procedures Online
Subjects:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
VSV-eGFP-SARS-CoV-2
Human angiotensin-converting enzyme 2
Biosafety level 2 (BSL-2)
High-throughput drug screening, Reporter assay system, Syncytia, Molecular simulation
Online Access:https://doi.org/10.1186/s12575-023-00214-1

Internet

https://doi.org/10.1186/s12575-023-00214-1

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