HIV-1 Protease as DNA Immunogen against Drug Resistance in HIV-1 Infection: DNA Immunization with Drug Resistant HIV-1 Protease Protects Mice from Challenge with Protease-Expressing Cells

HIV-1 Protease as DNA Immunogen against Drug Resistance in HIV-1 Infection: DNA Immunization with Drug Resistant HIV-1 Protease Protects Mice from Challenge with Protease-Expressing Cells

DNA immunization with HIV-1 protease (PR) is advanced for immunotherapy of HIV-1 infection to reduce the number of infected cells producing drug-resistant virus. A consensus PR of the HIV-1 FSU_A strain was designed, expression-optimized, inactivated (D25N), and supplemented with drug resistance (DR...

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Bibliographic Details
Main Authors: Stefan Petkov, Athina Kilpeläinen, Ekaterina Bayurova, Anastasia Latanova, Dzeina Mezale, Ilse Fridrihsone, Elizaveta Starodubova, Juris Jansons, Alesja Dudorova, Ilya Gordeychuk, Britta Wahren, Maria Isaguliants
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
HIV-1
drug resistance
protease
DNA immunogen
CD8+ T-cell response
mammary gland adenocarcinoma 4T1luc2 cells
Online Access:https://www.mdpi.com/2072-6694/15/1/238

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https://www.mdpi.com/2072-6694/15/1/238

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