GPX4 suppresses ferroptosis to promote malignant progression of endometrial carcinoma via transcriptional activation by ELK1

GPX4 suppresses ferroptosis to promote malignant progression of endometrial carcinoma via transcriptional activation by ELK1

Abstract Background Glutathione Peroxidase 4 (GPX4) is a key protein that inhibits ferroptosis. However, its biological regulation and mechanism in endometrial cancer (EC) have not been reported in detail. Methods The expression of GPX4 in EC tissues was determined by TCGA databases, qRT-PCR, Wester...

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Bibliographic Details
Main Authors: Sitian Wei, Zhicheng Yu, Rui Shi, Lanfen An, Qi Zhang, Qian Zhang, Tangansu Zhang, Jun Zhang, Hongbo Wang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Cancer
Subjects:
Endometrial carcinoma
GPX4
ELK1
Ferroptosis
Transcriptional activation
Online Access:https://doi.org/10.1186/s12885-022-09986-3

Internet

https://doi.org/10.1186/s12885-022-09986-3

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