Dynamics design of a non-natural transcription factor responding to androst-4-ene-3,17-dione

Dynamics design of a non-natural transcription factor responding to androst-4-ene-3,17-dione

The production of androst-4-ene-3,17-dione (AD) by the steroidal microbial cell factory requires transcription factors (TFs) to participate in metabolic regulation. However, microbial cell factory lacks effective TFs that can respond to AD in its metabolic pathway. Additionally, finding and obtainin...

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Bibliographic Details
Main Authors: Ming Zhao, Mengkai Hu, Rumeng Han, Chao Ye, Xiangfei Li, Tianwen Wang, Yan Liu, Zhenglian Xue, Kun Liu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-09-01
Series:Synthetic and Systems Biotechnology
Subjects:
Protein design
Artificial transcription factor
Molecular dynamics
Steriods
Site-mutations
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X24000528

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http://www.sciencedirect.com/science/article/pii/S2405805X24000528

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