Bivalent EGFR-Targeting DARPin-MMAE Conjugates

Bivalent EGFR-Targeting DARPin-MMAE Conjugates

Epidermal growth factor receptor (EGFR) is a validated tumor marker overexpressed in various cancers such as squamous cell carcinoma (SSC) of the head and neck and gliomas. We constructed protein-drug conjugates based on the anti-EGFR Designed Ankyrin Repeat Protein (DARPin) E01, and compared the bi...

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Bibliographic Details
Main Authors: Lennard Karsten, Nils Janson, Vadim Le Joncour, Sarfaraz Alam, Benjamin Müller, Jayendrakishore Tanjore Ramanathan, Pirjo Laakkonen, Norbert Sewald, Kristian M. Müller
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
EGFR
DARPin
antibody-drug conjugates
MMAE conjugates
Knoevenagel ligation
formylglycine-generating enzyme
Online Access:https://www.mdpi.com/1422-0067/23/5/2468

Internet

https://www.mdpi.com/1422-0067/23/5/2468

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