A selectivity filter at the intracellular end of the acid-sensing ion channel pore

A selectivity filter at the intracellular end of the acid-sensing ion channel pore

Increased extracellular proton concentrations during neurotransmission are converted to excitatory sodium influx by acid-sensing ion channels (ASICs). 10-fold sodium/potassium selectivity in ASICs has long been attributed to a central constriction in the channel pore, but experimental verification i...

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Bibliographic Details
Main Authors: Timothy Lynagh, Emelie Flood, Céline Boiteux, Matthias Wulf, Vitaly V Komnatnyy, Janne M Colding, Toby W Allen, Stephan A Pless
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
ACIC
ENaC/DEG
sodium selectivity
ion permeation
unnatural amino acids
molecular dynamics
Online Access:https://elifesciences.org/articles/24630

Internet

https://elifesciences.org/articles/24630

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