Quantification and modeling of macroparticle-induced mechanical stress for varying shake flask cultivation conditions

Quantification and modeling of macroparticle-induced mechanical stress for varying shake flask cultivation conditions

In biotechnological processes, filamentous microorganisms are known for their broad product spectrum and complex cellular morphology. Product formation and cellular morphology are often closely linked, requiring a well-defined level of mechanical stress to achieve high product concentrations. Macrop...

Full description

Bibliographic Details
Main Authors: Marcel Schrader, Kathrin Schrinner, Laura Polomsky, Dimitri Ivanov, Ingo Kampen, Carsten Schilde, Rainer Krull, Arno Kwade
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
macroparticle-enhanced cultivation
CFD-DEM simulation
shake flask
mechanical stress
filamentous microorganism
rebeccamycin
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1254136/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1254136/full

Similar Items