Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial–mesenchymal transition and subcellular re-localization of Beta-Catenin

Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial–mesenchymal transition and subcellular re-localization of Beta-Catenin

DNA methyltransferase I plays the central role in maintenance of CpG DNA methylation patterns across the genome and alteration of CpG methylation patterns is a frequent and significant occurrence across many cancers. Cancer cells carrying hypomorphic alleles of Dnmt1 have become important tools for...

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Bibliographic Details
Main Authors: Emily H Bowler, Alex Smith-Vidal, Alex Lester, Joseph Bell, Zhenghe Wang, Christopher G. Bell, Yihua Wang, Nullin Divecha, Paul J. Skipp, Rob M. Ewing
Format: Article
Language:English
Published: Taylor & Francis Group 2020-02-01
Series:Epigenetics
Subjects:
dna methyltransferase
beta-catenin
epithelial-mesenchymal transition
proteomics
Online Access:http://dx.doi.org/10.1080/15592294.2019.1656154

Internet

http://dx.doi.org/10.1080/15592294.2019.1656154

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