Listeria monocytogenes folate metabolism is required to generate N-formylmethionine during infection

ABSTRACT Folic acid and its derivatives are required for the synthesis of purines, pyrimidines, and some amino acids. Antifolate antibiotics that target the folic acid metabolism pathway are commonly used for the treatment of listeriosis caused by the intracellular pathogen Listeria monocytogenes (L...

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Bibliographic Details
Main Authors: Qing Tang, Michelle L. Reniere
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mbio.01385-23