Pro-inflammatory Monocyte Phenotype and Cell-Specific Steroid Signaling Alterations in Unmedicated Patients With Major Depressive Disorder

Pro-inflammatory Monocyte Phenotype and Cell-Specific Steroid Signaling Alterations in Unmedicated Patients With Major Depressive Disorder

Several lines of evidence have strongly implicated inflammatory processes in the pathobiology of major depressive disorder (MDD). However, the cellular origin of inflammatory signals and their specificity remain unclear. We examined the phenotype and glucocorticoid signaling in key cell populations...

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Bibliographic Details
Main Authors: Helge Hasselmann, Stefanie Gamradt, Aline Taenzer, Jan Nowacki, Rami Zain, Kostas Patas, Caren Ramien, Friedemann Paul, Katja Wingenfeld, Dominique Piber, Stefan M. Gold, Christian Otte
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
depression
monocytes
inflammation
steroid hormones
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02693/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02693/full

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