The ASC Speck and NLRP3 Inflammasome Function Are Spatially and Temporally Distinct

The ASC Speck and NLRP3 Inflammasome Function Are Spatially and Temporally Distinct

Although considered the ternary inflammasome structure, whether the singular, perinuclear NLRP3:ASC speck is synonymous with the NLRP3 inflammasome is unclear. Herein, we report that the NLRP3:ASC speck is not required for nigericin-induced inflammasome activation but facilitates and maximizes IL-1β...

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Bibliographic Details
Main Authors: Abhinit Nagar, Tabassum Rahman, Jonathan A. Harton
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
speck
NLRP3
inflammasome
caspase-1
colchicine
IL-1β
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.752482/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.752482/full

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