TRIM21‐Promoted FSP1 Plasma Membrane Translocation Confers Ferroptosis Resistance in Human Cancers

TRIM21‐Promoted FSP1 Plasma Membrane Translocation Confers Ferroptosis Resistance in Human Cancers

Abstract Ferroptosis, an iron‐dependent form of regulated cell death driven by excessive accumulation of lipid peroxides, has become a promising strategy in cancer treatment. Cancer cells exploit antioxidant proteins, including Ferroptosis Suppressor Protein 1 (FSP1), to prevent ferroptosis. In this...

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Bibliographic Details
Main Authors: Jun Gong, Yuhui Liu, Wenjia Wang, Ruizhi He, Qilong Xia, Lin Chen, Chunle Zhao, Yang Gao, Yongkang Shi, Yu Bai, Yangwei Liao, Qi Zhang, Feng Zhu, Min Wang, Xu Li, Renyi Qin
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Advanced Science
Subjects:
cancer
ferroptosis
FSP1
TRIM21
ubiquitination
Online Access:https://doi.org/10.1002/advs.202302318

Internet

https://doi.org/10.1002/advs.202302318

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