Approach to Strain Selection and the Propagation of Viral Stocks for Venezuelan Equine Encephalitis Virus Vaccine Efficacy Testing under the Animal Rule

Approach to Strain Selection and the Propagation of Viral Stocks for Venezuelan Equine Encephalitis Virus Vaccine Efficacy Testing under the Animal Rule

Licensure of a vaccine to protect against aerosolized Venezuelan equine encephalitis virus (VEEV) requires use of the U.S. Food and Drug Administration (FDA) Animal Rule to assess vaccine efficacy as human studies are not feasible or ethical. An approach to selecting VEEV challenge strains for use u...

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Bibliographic Details
Main Authors: Janice M. Rusnak, Pamela J. Glass, Scott C. Weaver, Carol L. Sabourin, Andrew M. Glenn, William Klimstra, Christopher S. Badorrek, Farooq Nasar, Lucy A. Ward
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Viruses
Subjects:
Venezuelan equine encephalitis virus
vaccine
strain selection
Animal Rule
cDNA cloned virus
virus stock propagation
Online Access:https://www.mdpi.com/1999-4915/11/9/807

Internet

https://www.mdpi.com/1999-4915/11/9/807

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