Effective therapeutic approach for head and neck cancer by an engineered minibody targeting the EGFR receptor.

Effective therapeutic approach for head and neck cancer by an engineered minibody targeting the EGFR receptor.

Cetuximab, a chimeric monoclonal antibody developed for targeting the Epidermal Growth Factor Receptor (EGFR), has been intensively used to treat cancer patients with metastatic colorectal cancer and head and neck cancer. Intact immunoglobulin G (IgG) antibody like cetuximab, however, has some limit...

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Bibliographic Details
Main Authors: Young Pil Kim, Dongsun Park, Jae Jin Kim, Won-Jae Chi, Sun Hee Lee, Seo Yun Lee, Soyeon Kim, Jee Min Chung, Jinseon Jeon, Byoung Dae Lee, Joo-Ho Shin, Yun-Il Lee, Hyeseong Cho, Jeong-Min Lee, Ho Chul Kang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0113442&type=printable

Internet

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0113442&type=printable

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