Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism

Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism

Abstract Increased excitatory neuronal tones have been implicated in autism, but its mechanism remains elusive. The amplified glutamate signals may arise from enhanced glutamatergic circuits, which can be affected by astrocyte activation and suppressive signaling of dopamine neurotransmission. We te...

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Bibliographic Details
Main Authors: Masaki Oya, Kiwamu Matsuoka, Manabu Kubota, Junya Fujino, Shisei Tei, Keisuke Takahata, Kenji Tagai, Yasuharu Yamamoto, Hitoshi Shimada, Chie Seki, Takashi Itahashi, Yuta Y. Aoki, Haruhisa Ohta, Ryu-ichiro Hashimoto, Genichi Sugihara, Takayuki Obata, Ming-Rong Zhang, Tetsuya Suhara, Motoaki Nakamura, Nobumasa Kato, Yuhei Takado, Hidehiko Takahashi, Makoto Higuchi
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-38306-3

Internet

https://doi.org/10.1038/s41598-023-38306-3

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