Unveiling the Role of Nonionic Surfactants in Enhancing Cefotaxime Drug Solubility: A UV-Visible Spectroscopic Investigation in Single and Mixed Micellar Formulations

Unveiling the Role of Nonionic Surfactants in Enhancing Cefotaxime Drug Solubility: A UV-Visible Spectroscopic Investigation in Single and Mixed Micellar Formulations

This study reports the interfacial phenomenon of cefotaxime in combination with nonionic surfactants, Triton X-100 (TX-100) and Tween-80 (TW-80), and their mixed micellar formulations. Cefotaxime was enclosed in a micellar system to improve its solubility and effectiveness. TX-100 and TW-80 were use...

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Bibliographic Details
Main Authors: Aysha Arshad Rana, Amnah Yusaf, Salma Shahid, Muhammad Usman, Matloob Ahmad, Sana Aslam, Sami A. Al-Hussain, Magdi E. A. Zaki
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceuticals
Subjects:
cefotaxime
solubilization
nonionic surfactants
mixed micelle
drug delivery
encapsulation efficiency
Online Access:https://www.mdpi.com/1424-8247/16/12/1663

Internet

https://www.mdpi.com/1424-8247/16/12/1663

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