Dynamics and Molecular Interactions of GPI-Anchored CD59
CD59 is a GPI-anchored cell surface receptor that serves as a gatekeeper to controlling pore formation. It is the only membrane-bound inhibitor of the complement membrane attack complex (MAC), an immune pore that can damage human cells. While CD59 blocks MAC pores, the receptor is co-opted by bacter...
Main Authors: | Tomas B. Voisin, Emma C. Couves, Edward W. Tate, Doryen Bubeck |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-06-01
|
Series: | Toxins |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6651/15/7/430 |
Similar Items
-
Ancient but Not Forgotten: New Insights Into MPEG1, a Macrophage Perforin-Like Immune Effector
by: Charles Bayly-Jones, et al.
Published: (2020-10-01) -
Soluble Membrane Attack Complex: Biochemistry and Immunobiology
by: Scott R. Barnum, et al.
Published: (2020-11-01) -
Editorial: Perforins and Cholesterol-Dependent Cytolysins in Immunity and Pathogenesis
by: George P. Munson, et al.
Published: (2022-06-01) -
The Cytolytic Activity of Vaginolysin Strictly Depends on Cholesterol and Is Potentiated by Human CD59
by: Milda Zilnyte, et al.
Published: (2015-01-01) -
An Inducible Cre-<i>lox</i> System to Analyze the Role of LLO in <i>Listeria monocytogenes</i> Pathogenesis
by: Brittney N. Nguyen, et al.
Published: (2020-01-01)