Pyrrole-based inhibitors of RND-type efflux pumps reverse antibiotic resistance and display anti-virulence potential.

Pyrrole-based inhibitors of RND-type efflux pumps reverse antibiotic resistance and display anti-virulence potential.

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Efflux pumps of the resistance-nodulation-cell division (RND) superfamily, particularly the AcrAB-TolC, and MexAB-OprM, besides mediating intrinsic and acquired resistance, also intervene in bacterial pathogenicity. Inhibitors of such pumps could restore the activities of antibiotics and curb bacter...

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Main Authors: Nisha Mahey, Rushikesh Tambat, Ritu Kalia, Rajnita Ingavale, Akriti Kodesia, Nishtha Chandal, Srajan Kapoor, Dipesh Kumar Verma, Krishan Gopal Thakur, Sanjay Jachak, Hemraj Nandanwar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-04-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012121&type=printable

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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012121&type=printable

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